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The Localization of the Site of ArylalkylamineN-Acetyltransferase Circadian Expression in the Photoreceptor Cells of Mammalian Retina
Where the daily cycle of a key enzyme happens in light-sensing cells of the mammal eye
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Abstract
AA-NAT mRNA levels in the rat retina increased more than threefold at night.
- AA-NAT is the rate-limiting enzyme for melatonin synthesis in mammals.
- mRNA for AA-NAT was found exclusively in the retinal photoreceptors.
- AA-NAT expression was low during the day and significantly higher at night.
- The nocturnal expression of AA-NAT was confirmed through additional techniques.
- This finding is the first to pinpoint the location of circadian AA-NAT expression in mammalian photoreceptor cells.
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