Association of Life’s Essential 8 and Simple 7 Scores With Mortality

Jun 28, 2024JACC. Advances

How Life's Essential 8 and Simple 7 Heart Health Scores Relate to Death Rates Compared to the Pooled Cohort Equation

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 21,721 individuals, the C-statistics for all-cause mortality were 0.823 for the Life's Essential 8 (LE8) score and 0.819 for the Life's Simple 7 (LS7) score.

Both LE8 and LS7 scores demonstrated similar effectiveness in predicting all-cause and cardiovascular mortality.
For cardiovascular mortality, the LE8 score had a C-statistic of 0.887, while the LS7 score was at 0.883.
In a subgroup of 12,943 individuals aged 40 to 79 years, the Pooled Cohort Equations (PCE) showed a C-statistic of 0.756 for all-cause mortality.
The LS7 score and LE8 score had lower C-statistics of 0.674 and 0.681, respectively, in the same age group.
PCE may offer better risk prediction for all-cause mortality compared to both LE8 and LS7 scores in individuals aged 40 to 79.

AI simplified

BACKGROUND: In 2022, the Life's Simple 7 (LS7) score was replaced with the Life's Essential 8 (LE8) score as a tool to measure cardiovascular health. The risk prediction values of LE8 and LS7 scores for mortality have not been compared. Additionally, the risk prediction value of these scores has not been compared with the pooled cohort equations (PCE) in individuals aged 40 to 79 years.

OBJECTIVES: This study compared the risk prediction value of the: 1) LE8 and LS7 scores in the overall population; and 2) LE8 score, LS7 score, and PCE in the 40- to 79-year-old age group for all-cause and cardiovascular mortality in a nationally representative US population.

METHODS: The LS7 and LE8 scores and the PCE were calculated in the National Health and Nutrition Examination Survey cycles 2007 to 2018. All-cause and cardiovascular mortality were identified by linking the participants to the National Death Index. The C-statistics of the respective weighted Cox models were used to compare the risk prediction value of the standardized scores.

RESULTS: Among 21,721 individuals included, the C-statistics for all-cause mortality were 0.823 (95% CI: 0.803-0.843) and 0.819 (95% CI: 0.799-0.838) in the LE8 and LS7 score-based models, respectively. The C-statistics for cardiovascular mortality were 0.887 (95% CI: 0.857-0.905) for the LE8 score-based model and 0.883 (95% CI: 0.861-0.905) for the LS7 score-based model. Among 12,943 individuals aged 40 to 79 years, the C-statistics for the outcome of all-cause mortality were 0.756 (95% CI: 0.732-0.779), 0.674 (95% CI: 0.646-0.701), and 0.681 (95% CI: 0.656-0.706) for the PCE, LS7 score, and LE8 score-based models, respectively.

CONCLUSIONS: The LS7 and LE8 scores had similar risk prediction values for all-cause and cardiovascular mortality. Among 40- to 79-year-old individuals, the PCE had better risk discrimination in the LE8 and LS7 scores in predicting all-cause mortality.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Association of Life’s Essential 8 and Simple 7 Scores With Mortality

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief