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Abstract
Most epigenetic clocks showed only low to moderate biological reliability, which is critical for their clinical application.
- Technical reproducibility was excellent for most clocks across different DNA methylation assays.
- Certain clocks exhibited sensitivity to experimental factors, affecting their reliability.
- PC-based clocks, particularly PCGrimAge and SystemsAge, displayed robustness under various conditions.
- Biological reliability was significantly lower, especially when accounting for immune composition.
- Clocks with higher reliability were associated with more stable cognitive outcomes and consistent intervention responses.
- Improving biological reliability is essential for enhancing the clinical utility of epigenetic clocks.
Simplified
Longevity & Aging