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BMAL1 dephosphorylation determines the pace of the circadian clock
Removing a phosphate from BMAL1 controls the speed of the body’s daily clock
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Abstract
Dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) is involved in modulating circadian timing.
- Circadian clocks in mammals operate through self-sustained oscillators in nearly all body cells.
- These oscillators rely on delayed negative feedback loops in gene expression for their function.
- Both transcriptional activation and repression are essential for maintaining circadian rhythms.
- Post-translational modifications, particularly phosphorylation by protein kinases, significantly influence the pace of circadian clocks.
- The study highlights the specific role of PPP4 in the dephosphorylation of BMAL1 as a regulatory mechanism for circadian timing.
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