c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level

c-MYC may repress the transcription of the circadian gene Per1 in a manner dependent on its interaction with the BMAL1/CLOCK complex.

• Cell proliferation in mammals follows a circadian rhythm, and disruptions in clock gene expression have been linked to tumor development.
• The c-Myc oncogene is often deregulated in tumors, leading to abnormal cell growth.
• BMAL1, a core circadian factor, has been shown to bind to the human c-Myc promoter in vivo.
• Analysis indicates that the clock regulates cellular levels of MYC through protein synthesis, degradation rates, and acetylation.
• c-MYC can repress the transactivation of Per1 by targeting specific E-box sequences when overexpressed.
• This interaction between MYC and circadian transactivators could explain the deregulated expression of clock genes in various cancers.

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