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Circadian regulation of c-MYC in mice
Daily rhythms controlling c-MYC levels in mice
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Abstract
Mutation of specific clock genes results in significant changes to c-MYC protein levels in mouse spleen.
- Down-regulation of c-MYC occurs with mutations that disrupt the negative feedback loop of the circadian clock.
- Up-regulation of c-MYC is observed with mutations that affect the positive feedback loop of the circadian clock.
- The circadian clock regulates the expression of a substantial portion of transcripts, including oncogenes and tumor suppressors.
- These results suggest that alterations in clock gene function may influence tumorigenesis through changes in c-MYC levels.
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