Calcitonin receptors help control temperature preferences in insects and body temperature in mammals

The diuretic hormone 31 receptor (DH31R) is essential for regulating temperature preference rhythm during the active phase.

• BTR is crucial for maintaining homeostasis and is regulated independently from locomotor activity rhythms.
• In ectotherms, temperature preference rhythm (TPR) behavior helps regulate BTR.
• DH31R is expressed in clock cells and influences TPR during the active phase.
• The mouse equivalent of DH31R, called calcitonin receptor (Calcr), is found in the suprachiasmatic nucleus and affects body temperature fluctuations during the active phase.
• Both DH31R and Calcr are not necessary for coordinating locomotor activity rhythms.
• This study provides the first molecular evidence indicating that BTR regulation is distinct from locomotor activity rhythms.

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