Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

The diuretic hormone 31 receptor (DH31R) is essential for regulating temperature preference rhythm during the active phase.

• BTR is crucial for maintaining homeostasis and is regulated independently from locomotor activity rhythms.
• In ectotherms, temperature preference rhythm (TPR) behavior helps regulate BTR.
• DH31R is expressed in clock cells and influences TPR during the active phase.
• The mouse equivalent of DH31R, called calcitonin receptor (Calcr), is found in the suprachiasmatic nucleus and affects body temperature fluctuations during the active phase.
• Both DH31R and Calcr are not necessary for coordinating locomotor activity rhythms.
• This study provides the first molecular evidence indicating that BTR regulation is distinct from locomotor activity rhythms.

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