The emerging link between cancer, metabolism, and circadian rhythms

Dec 8, 2018Nature medicine

The growing connection between cancer, body energy use, and daily biological clocks

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Abstract

Disruption of circadian rhythms is associated with cancer according to epidemiological and clinical data.

  • Circadian rhythms regulate various metabolic and gene expression pathways linked to physiological processes.
  • Preclinical data support the connection between circadian rhythm disruption and cancer.
  • Animal models and molecular studies highlight emerging links between cancer metabolism and the circadian clock.
  • Potential therapeutic approaches may involve chronopharmacological strategies.

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