The Cardiac Circadian Clock Regulates Rhythms in Peripheral Tissues via Fibulin 5

Bmal1 cKO mice exhibited attenuated day-night differences in skeletal muscle core clock gene expression and impaired muscle grip strength.

• The cardiac clock appears to influence circadian function in peripheral tissues.
• Bmal1 cKO mice showed reduced expression of core clock and metabolic genes in skeletal muscle.
• Impaired day-night muscle grip strength was observed in Bmal1 cKO mice.
• In the kidney, core clock and water balance gene expression were diminished in Bmal1 cKO mice.
• Fibulin 5 (Fbln5) was identified as a potential cardiokine affecting peripheral circadian rhythms.
• Disruption of Fbln5 expression in both the heart and serum of Bmal1 cKO mice was noted, impacting rhythmic clock gene expression.

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