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Cardiovascular health and cancer mortality: evidence from US NHANES and UK Biobank cohort studies
Links between heart health and cancer death in US and UK population studies
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Abstract
High (CVH) is associated with a substantial reduction in overall cancer mortality risk.
- A total of 424 cancer-related deaths occurred in US NHANES participants over 141,526 person-years, while UK Biobank reported 8,872 cancer deaths during 3,690,893 person-years.
- High CVH is linked to a reduction in overall cancer mortality, with hazard ratios of 0.58 in US NHANES and 0.51 in UK Biobank compared to low CVH.
- Each one-standard deviation increase in CVH score is associated with a 19% decrease in cancer mortality in both US NHANES and UK Biobank.
- Adherence to ideal CVH shows a linear association with decreased risks of death from various cancer types, including lung, breast, and colorectal cancers.
- Individuals with low genetic risk and high CVH have the lowest cancer mortality rates, with hazard ratios ranging from 0.36 to 0.57.
- Younger participants and those with lower socio-economic status exhibited a more pronounced protective association between high CVH and reduced overall cancer mortality.
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Key numbers
19%
Decrease in Cancer Mortality Risk per SD Increase in Score
Observed in both US NHANES and UK Biobank cohorts.
0.51
Lower Risk of Cancer Mortality in High
Hazard ratio indicates significant protective association.
0.36 to 0.57
Lower Risk of Cancer Mortality in Younger Individuals
Hazard ratios indicate protective effects across various cancer types.