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Association of Life’s Essential 8 with incidence of heart failure modified by depressive symptoms: a prospective cohort study from UK Biobank
Links between Life's Essential 8 and new heart failure cases may change with depression symptoms
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Abstract
A total of 9,379 (2.8%) participants developed during a median follow-up of 13.6 years.
- Higher cardiovascular health (CVH) scores, categorized as moderate and high, are associated with a significantly lower risk of heart failure compared to low CVH scores.
- Specifically, moderate CVH scores are linked to a 40.4% reduced risk ( 0.596), while high CVH scores are associated with a 54.2% reduced risk (hazard ratio 0.458) of heart failure.
- Each standard deviation increase in the (LE8) score correlates with a 25.5% lower risk of developing heart failure.
- Participants with low CVH and depressive symptoms show a greater risk for heart failure compared to those without depressive symptoms.
- The lowest risk of heart failure is found in individuals with high CVH scores and no depressive symptoms, indicating a protective effect.
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Key numbers
0.458
Lower Risk of with High CVH
for incident in high CVH vs. low CVH
9379 of 336,939
Incidence in Study Population
Total cases of during the study follow-up
25.5%
Risk Reduction per SD Increment in
Percentage reduction in risk per standard deviation increase in score