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On the role of Cdc2 kinase during meiotic maturation of oocyte in the Chinese mitten crab, Eriocheir sinensis
The role of Cdc2 kinase in egg cell maturation in the Chinese mitten crab
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Abstract
The crab Cdc2 cDNA is 1364 bp long and encodes a protein of 299 amino acids.
- Cdc2 mRNA levels remain stable during oogenesis in the ovary.
- Protein levels of Cdc2 kinase are higher during specific stages, including previtellogenesis, late vitellogenesis, and germinal vesicle breakdown.
- Two forms of Cdc2 proteins (35 kDa and 34 kDa) are present at all ovarian stages.
- Cdc2 proteins are found only in the ooplasm of previtellogenic oocytes and later relocate to the germinal vesicle and meiotic spindle during maturation.
- These observations indicate that Cdc2 kinase may play critical roles in triggering germinal vesicle breakdown and forming the meiotic apparatus.
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