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Cell autonomous regulation of herpes and influenza virus infection by the circadian clock
How the body's internal clock controls herpes and flu virus infections within individual cells
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Abstract
Host infection time significantly influences virus progression in live mice and individual cells.
- Circadian rhythms (∼24 h cycles) in host physiology are not constant and affect viral replication.
- Herpes and influenza A virus infections increase when the key clock gene Bmal1 is disrupted.
- Processes such as intracellular trafficking, protein synthesis, and chromatin assembly are regulated by circadian rhythms and contribute to virus infection.
- Herpesviruses specifically target components of the molecular circadian clock.
- Viral exploitation of the host's circadian clock suggests it may serve as a new target for controlling viral replication.
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