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CLOCK:BMAL1 is a pioneer-like transcription factor
CLOCK:BMAL1 acts as a pioneering gene regulator
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Abstract
Rhythmic CLOCK:BMAL1 DNA binding is associated with rhythmic chromatin opening.
- CLOCK and BMAL1 are master genes that regulate biological functions within the circadian clock.
- Binding of CLOCK:BMAL1 to nucleosomes is linked to rhythmic chromatin modifications.
- Incorporation of the histone variant H2A.Z is observed as part of the chromatin remodeling process.
- Other transcription factors can bind rhythmically adjacent to CLOCK:BMAL1, influencing gene expression.
- Findings suggest that circadian regulation of transcription is connected to changes in chromatin accessibility.
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