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Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
Rhythmic binding of CLOCK-BMAL1 to DNA sites controls daily Dbp gene activity and DNA structure changes
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Abstract
Circadian regulation of the mouse Dbp gene involves rhythmic binding of BMAL1 and CLOCK proteins.
- BMAL1 and CLOCK proteins rhythmically bind to multiple E boxes associated with the Dbp gene.
- Daily changes in chromatin structure are observed, with acetylation of histone H3 at Lys9 and trimethylation at Lys4 during transcription activation.
- A reduction in histone density occurs during the transcription cycle of the Dbp gene.
- Daily repression of Dbp transcription is marked by dimethylation of histone H3 at Lys9 and increased binding of heterochromatin protein 1alpha.
- The conversion of chromatin from a transcriptionally active state to facultative heterochromatin is dependent on functional BMAL1-CLOCK binding sites.
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