Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response

Jan 25, 2016Methods in molecular biology (Clifton, N.J.)

How Cellular Molecular Clocks May Influence the Innate Immune Response

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Circadian rhythms significantly influence immune function, particularly in response to bacterial challenges.

  • Immune parameters vary with the time of day, affecting immune cell behavior and responses.
  • Disruption of circadian rhythms is linked to inflammatory diseases.
  • Key proteins like BMAL1, CLOCK, and REV-ERBα are involved in regulating the immune response.
  • Understanding the immune system's daily rhythm may enhance patient care for vaccinations and infectious diseases.
  • Initial experiments are underway to assess the molecular clock's role in immune responses across different cell types.

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