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Molecular Links Between the Body’s Internal Clock and the Immune System
Updated
Abstract
The immune system is influenced by the circadian clock through multiple molecular interactions.
- Circadian rhythms in the immune system are linked to direct interactions between circadian clock components and immune system components.
- Circadian clock proteins function as transcription factors, regulating the expression or repression of immune genes.
- Histone modifications, such as acetylation and methylation, are involved in circadian control of gene transcription and inflammatory proteins.
- Circadian clock proteins can physically interact with key inflammatory pathways, including members of the NFκB protein family.
- The immune system may also influence circadian clock function, indicating a reciprocal relationship between the two systems.
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