Diabetes, obesity & metabolism

Key molecules that control the daily biological clock in mammals

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The circadian clock in mouse liver regulates thousands of genes through interactions of bHLH-PAS proteins CLOCK and BMAL1.

  • CLOCK and BMAL1 form a complex that activates the transcription of Period and Cryptochrome genes.
  • This transcriptional feedback loop results in the repression of their own transcription.
  • Circadian transcription in the liver is coordinated over time and linked to RNA polymerase II activity.
  • Fluctuations in histone modifications, such as H3K4me3, H3K9ac, and H3K27ac, are associated with these transcriptional changes.
  • The circadian clock influences both global transcriptional dynamics and chromatin structure.

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Funding

Competing interests

Conflict of Interest Statement . J.S.T. is a co-founder and SAB member of Reset Therapeutics, Inc.
PubMed

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