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Molecular components of the circadian clock in mammals
Key molecules that control the daily biological clock in mammals
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Abstract
The circadian clock in mouse liver regulates thousands of genes through interactions of bHLH-PAS proteins CLOCK and BMAL1.
- CLOCK and BMAL1 form a complex that activates the transcription of Period and Cryptochrome genes.
- This transcriptional feedback loop results in the repression of their own transcription.
- Circadian transcription in the liver is coordinated over time and linked to RNA polymerase II activity.
- Fluctuations in histone modifications, such as H3K4me3, H3K9ac, and H3K27ac, are associated with these transcriptional changes.
- The circadian clock influences both global transcriptional dynamics and chromatin structure.
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