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Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals
Gene activity and DNA structure of the main internal body clock in mammals
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Abstract
Only 22% of cycling messenger RNA (mRNA) genes in the mammalian circadian clock are driven by new transcription.
- The circadian transcriptional cycle in mouse liver consists of three distinct phases: poised, transcriptional activation, and repressed.
- Transcription factor binding and RNA polymerase II recruitment exhibit a time-dependent pattern throughout the circadian cycle.
- Circadian modulation affects chromatin states on a genome-wide scale, surpassing previous observations from gene expression profiling.
- Both transcriptional and posttranscriptional mechanisms may play roles in regulating the mammalian circadian clock.
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