Transcriptional architecture of the mammalian circadian clock

Genome-wide analyses reveal a global circadian regulation of processes associated with metabolism and cell growth.

• Circadian clocks are internal systems that manage 24-hour cycles in physiology and behavior.
• These clocks operate through a feedback mechanism involving the regulation of gene expression.
• Next-generation sequencing has enhanced understanding of the biochemical and genomic aspects of circadian function.
• Key processes influenced by circadian regulation include transcription factor activity, RNA polymerase II behavior, and chromatin structure changes.
• The targets of circadian clocks are widespread and closely linked to various metabolic and physiological processes.

AI simplified