Progress and challenges in understanding how the body’s internal clock and immune system are connected

Circadian disruption is linked to the development of inflammatory diseases like metabolic syndrome and cancer.

• Individuals with continuous disruption of their internal clock may have a higher risk of developing inflammatory diseases.
• Daily variations in susceptibility to infections and other immune processes have been documented.
• Various mechanisms have been suggested to explain how circadian rhythms influence immunity.
• A better understanding of the relationship between circadian and immune systems could lead to strategies for preventing and treating inflammatory diseases.

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