Brain and body GLP-1 systems separately reduce eating

PPG neurons in mice encode satiation signals, primarily receiving input from specific vagal neurons.

• PPG neurons are linked to the perception of fullness during eating.
• These neurons primarily receive signals from oxytocin-receptor-expressing vagal neurons, not those with GLP-1 receptors.
• PPG neurons are not essential for the eating suppression effects of GLP-1 receptor agonists.
• Activation of PPG neurons enhances the suppression of eating beyond what is achieved with semaglutide alone.
• Central and peripheral GLP-1 systems may operate through separate gut-brain pathways.

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