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Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
Brain cells controlling GLP-1 in the brainstem reduce eating during stress and prevent very large meals
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Abstract
Selective ablation of PPG neurons in the brain significantly reduced active GLP-1 concentrations but did not affect daily food intake or body weight in mice.
- GLP-1-producing neurons in the nucleus tractus solitarii are the main source of GLP-1 in the brain.
- Loss of central GLP-1 did not impact daily chow intake or glucose tolerance under normal conditions.
- PPG neuron ablation led to increased food intake after prolonged fasting and following a liquid diet preload.
- Inhibition of PPG neurons did not affect normal feeding but increased intake during refeeding after fasting.
- Activation of PPG neurons caused a strong reduction in food intake, suggesting their role in a secondary satiation circuit.
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