The central clock drives metabolic rhythms in muscle stem cells

The 24-hour rhythm of metabolic genes in satellite cells is influenced by central clock inputs.

• Satellite cells, which are stem cells in skeletal muscle, display circadian oscillations in gene expression.
• The local satellite cell clock is not required for the rhythmicity of metabolic genes.
• Feeding-fasting cycles are identified as the primary output from the central clock that affects satellite cell function.
• Central signals are linked to the metabolic state of satellite cells and their ability to repair muscle.
• Intact autophagic function is necessary for the proper oscillation of metabolic transcripts in satellite cells.

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