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GLP-1’s role in brain signaling changes with body state to maintain energy balance
Updated
Abstract
Chemogenetic activation of the PVN→DVC circuit in mice suppresses feeding.
- GLP-1 receptor neurons in the paraventricular hypothalamic nucleus project to the dorsal vagal complex in the brain stem.
- Synapses in the PVN→DVC circuit release glutamate and their activity is enhanced by GLP-1.
- Under hunger conditions, the strength of synaptic connections is weaker but responds more strongly to GLP-1 receptor activation.
- In obesity, the synaptic adjustments in this pathway may become impaired.
- Optogenetic stimulation of the PVN→DVC projections reduces food intake in a manner dependent on the energy state.
- Blocking synaptic release or removing GLP-1 receptors in presynaptic neurons negatively affects metabolic health.
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