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Identification of choline-degrading bacteria from healthy human feces and used for screening of trimethylamine (TMA)-lyase inhibitors
Finding gut bacteria that break down choline and testing substances that block their trimethylamine production
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Abstract
TMA levels were significantly decreased when treated with β-sitosterol and resveratrol.
- Gut microbiota can convert choline to trimethylamine (TMA), which is then transformed into trimethylamine-N-oxide (TMAO), associated with cardiovascular disease (CVD).
- Choline-degrading bacteria were isolated from healthy human feces and identified as Klebsiella pneumoniae.
- An in silico and in vitro platform was established to screen for TMA-lyase inhibitors from Chinese herbal medicines.
- The inhibitory effects of selected compounds, β-sitosterol and resveratrol, were evaluated using K. pneumoniae as a bioassay indicator.
- This research demonstrates the potential of β-sitosterol and resveratrol to inhibit gut microbiota-mediated choline metabolism.
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