Chronic circadian stress impairs blood pressure and sodium homeostasis in a diet- and sex-specific manner

KO males on a normal fat diet show lower mean arterial pressure compared to WT under 12:12 light:dark conditions.

• Chronic circadian stress from a weekly 6-hour advance in light:dark cycles increases mean arterial pressure in KO males, eliminating initial genotype differences.
• In KO females, chronic circadian stress does not significantly affect mean arterial pressure or heart rate.
• High-fat diet diminishes genotype-based differences in mean arterial pressure and sex differences in heart rate.
• Chronic circadian stress increases mean arterial pressure in male KO rats, while also reducing blood pressure amplitude.
• Sodium excretion patterns are disrupted in both wild-type and KO males on a high-fat diet after chronic circadian stress.
• In KO females, chronic circadian stress combined with a high-fat diet disrupts sodium excretion rhythms, negating protective effects seen on a normal fat diet.

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