CHRONO integrates behavioral stress and epigenetic control of metabolism

Dec 25, 2016Annals of medicine

CHRONO links stress behavior and gene control of metabolism

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Chrono knockout mice display a longer period of circadian behavior and an elevated stress response.

  • Circadian rhythms, approximately 24 hours long, are essential for the body's homeostatic functions.
  • CHRONO is a novel circadian clock gene that interacts with other clock proteins to influence circadian mechanisms.
  • The transcription of CHRONO shows a strong circadian rhythm.
  • CHRONO acts as a repressor within the feedback loops that control circadian transcription and translation.
  • There is a potential link between CHRONO's epigenetic regulation and the body's response to stress.

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