Circadian biology and exercise: the time to move

May 4, 2026Life metabolism

How Body Clocks Influence Exercise and the Best Times to Be Active

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Abstract

Exercise performance varies by time of day in both humans and rodents.

  • Circadian biology significantly influences physiological responses to exercise timing.
  • The circadian clock may regulate exercise capacity by coordinating tissue-specific responses.
  • Fuel metabolism and mitochondrial production are linked to the timing of exercise.
  • Synchrony between circadian clocks and physiological pathways in muscle and other tissues could affect exercise performance.
  • Future individualized exercise protocols may be developed based on understanding these circadian mechanisms.

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