Important roles of the body’s internal clock in cancer

Circadian rhythms regulate physiological functions and are increasingly recognized for their role in cancer progression.

• The circadian clock affects cancer occurrence and progression through metabolic activities and gene expression.
• CLOCK and BMAL1 proteins are key components of the circadian clock associated with tumor diseases.
• The review discusses how the circadian clock interacts with anti-tumor treatments.
• Understanding these mechanisms may reveal new therapeutic targets for cancer treatment.

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