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Circadian clock dysfunction of epithelial cells in pulmonary diseases
Disrupted daily rhythms in lung lining cells in lung diseases
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Abstract
Circadian clock dysfunction in pulmonary epithelial cells is associated with various pulmonary diseases.
- Highly-differentiated pulmonary epithelial cells play crucial roles in lung health through various physiological functions.
- Key clock genes, such as BMAL1 and REV-ERB-α, regulate the inflammatory response in specific epithelial cell types.
- Dysfunction of the circadian clock in alveolar epithelial cells may contribute to increased susceptibility to airway inflammation and infections.
- Ciliated cells exhibit circadian rhythms in ciliary beat frequency, suggesting a link between timekeeping and respiratory function.
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