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The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway
The daily rhythm gene Bmal1 may help prevent pancreatic cancer by activating the p53 tumor suppressor
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Abstract
Bmal1 levels were downregulated in pancreatic cancer samples and correlated with patient clinicopathological features.
- Lower levels of Bmal1 are associated with tumor development in pancreatic cancer.
- Knockdown of Bmal1 in pancreatic cancer cells led to a transcriptome profile that promotes cell survival and proliferation.
- Overexpression of Bmal1 significantly inhibits cell proliferation and invasion and causes G2/M cell cycle arrest.
- Bmal1 is shown to directly bind to the promoter of the p53 gene, activating tumor suppressor pathways dependent on p53.
- Bmal1 may serve as an anti-oncogene and a potential biomarker for pancreatic cancer diagnosis.
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