Cancer letters

The daily rhythm gene Bmal1 may help prevent pancreatic cancer by activating the p53 tumor suppressor

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Bmal1 levels were downregulated in pancreatic cancer samples and correlated with patient clinicopathological features.

  • Lower levels of Bmal1 are associated with tumor development in pancreatic cancer.
  • Knockdown of Bmal1 in pancreatic cancer cells led to a transcriptome profile that promotes cell survival and proliferation.
  • Overexpression of Bmal1 significantly inhibits cell proliferation and invasion and causes G2/M cell cycle arrest.
  • Bmal1 is shown to directly bind to the promoter of the p53 gene, activating tumor suppressor pathways dependent on p53.
  • Bmal1 may serve as an anti-oncogene and a potential biomarker for pancreatic cancer diagnosis.

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