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Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
The Body’s Daily Rhythm Gene bmal1 May Help Prevent Brain Tumors in Mice
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Abstract
Disruption of the bmal1 gene in human GBM cells led to decreased survival and increased tumor growth in a mouse model.
- Loss of bmal1 expression resulted in worsened motor performance in male mice with GBM.
- Increased expression of the CD44 marker was observed in tumors with disrupted bmal1.
- Higher levels of astrocyte activation, indicated by GFAP expression, were associated with bmal1 disruption.
- Circadian disruption through constant light did not affect survival or tumor progression in mice with wild type GBM.
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