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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
How Changing BMAL1 Affects the Brain's Internal Clock and Behavior
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Abstract
Bmal1 is the only single circadian clock gene essential for rhythmic gene expression in mammals.
- Disruptions in circadian clock function may be linked to human mood disorders.
- Genetic manipulation of Bmal1 in mice could provide insights into depression-like behaviors.
- Various approaches to altering Bmal1 expression affect the brain's master circadian pacemaker.
- Changes in Bmal1 expression may impact circadian rhythms in other brain regions.
- Manipulating Bmal1 is associated with alterations in both circadian and mood-related behaviors.
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