Circadian clock in thyroid cancer: Effects and mechanisms

Circadian rhythm disruption is associated with an increased risk of thyroid cancer.

• The circadian clock regulates key physiological processes that are crucial for thyroid function.
• Shift work and exposure to artificial light at night may disrupt circadian rhythms.
• Disruption of these rhythms could contribute to thyroid carcinogenesis through various biological mechanisms.
• Molecular pathways connecting clock dysregulation to cancer include oncogenic signaling and immune evasion.
• Chronotherapy may serve as a potential precision oncology strategy targeting these disruptions.

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