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Abstract
Chronic circadian disruption is associated with increased risks of obesity, type 2 diabetes, and cancer.
- Circadian rhythms are driven by feedback loops of specific genes known as circadian clock genes.
- The central circadian pacemaker, located in the hypothalamic suprachiasmatic nucleus, regulates peripheral circadian clocks.
- Physiological processes are modulated by environmental factors such as light exposure and food timing.
- Daily TSH (thyroid-stimulating hormone) secretion profiles may be disrupted in some patients with thyroid disorders.
- Abnormal expression of circadian clock genes has been observed in well-differentiated thyroid cancer but not in benign nodules or healthy thyroid tissue.
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