The Journal of neuroscience : the official journal of the Society for Neuroscience

Daily rhythms control electrical activity in fruit fly brain clock cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

More than 50% of large lateral ventral clock neurons (lLN(v)s) exhibit two distinct sizes of action potentials.

  • Large action potentials originate in the ipsilateral optic lobe, while small action potentials come from the contralateral side.
  • Resting membrane potential (RMP), spontaneous firing rates, and membrane resistance of lLN(v)s are cyclically regulated based on the time of day in light/dark conditions.
  • As the day progresses from dawn to dusk, lLN(v) RMP becomes more hyperpolarized, with a decrease in spontaneous firing rate and membrane resistance.
  • From dusk to dawn, lLN(v) RMP becomes more depolarized, while the spontaneous firing rate and membrane resistance remain stable.
  • In circadian defective per(0) null mutant lLN(v)s, membrane excitability remains nearly constant in light/dark cycles.
  • In constant darkness, wild-type lLN(v) membrane excitability shows no cyclic regulation, though RMP gradually becomes slightly more depolarized.

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