Trends in endocrinology and metabolism: TEM

How Disrupted Body Clocks May Affect Heart and Blood Vessel Health

Updated

Abstract

Circadian misalignment is associated with increased cardiovascular risk factors.

  • The circadian system generates approximately 24-hour rhythms in nearly all biological processes.
  • Epidemiological studies indicate time-of-day variations in adverse cardiovascular events.
  • Controlled laboratory studies show that circadian rhythms influence key markers of cardiovascular function and risk.
  • Circadian disruption is typically experienced by shift workers and individuals with late eating or sleep disturbances.
  • Understanding how the circadian system regulates cardiovascular function could inform intervention strategies.

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Funding

Competing interests

Conflicts of interest. F.A.J.L.S. has received lecture fees from Bayer HealthCare, Sentara HealthCare, Philips, Vanda Pharmaceuticals, and Pfizer Pharmaceuticals. S.L.C, N.V and J.S.W report no conflicts of interest.
PubMed

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