Circadian Disruption and the Molecular Clock in Atherosclerosis and Hypertension

Circadian rhythms are crucial for maintaining vascular function and disruption of these rhythms is associated with negative health outcomes.

• Disruption of circadian rhythms is linked to cardiovascular disease and hypertension.
• Circadian rhythms are regulated by the central clock in the hypothalamus and peripheral clocks in nearly every cell type.
• Recent research highlights the connection between circadian disruption and molecular mechanisms involved in atherosclerosis and hypertension.
• Understanding daily behavioral rhythms, such as sleep and feeding, may influence cardiovascular risk.
• Potential future chronotherapeutics could target hypertension and vascular disease based on circadian biology.

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