Body Clock Disruption and Its Role in Hardening Arteries and High Blood Pressure

Circadian rhythms are crucial for maintaining vascular function and disruption of these rhythms is associated with negative health outcomes.

• Disruption of circadian rhythms is linked to cardiovascular disease and hypertension.
• Circadian rhythms are regulated by the central clock in the hypothalamus and peripheral clocks in nearly every cell type.
• Recent research highlights the connection between circadian disruption and molecular mechanisms involved in atherosclerosis and hypertension.
• Understanding daily behavioral rhythms, such as sleep and feeding, may influence cardiovascular risk.
• Potential future chronotherapeutics could target hypertension and vascular disease based on circadian biology.

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