Circadian orchestration of host and gut microbiota in infection

Sep 15, 2022Biological reviews of the Cambridge Philosophical Society

Daily rhythms of the body and gut bacteria during infection

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Abstract

Circadian rhythms regulate various biological processes and interact with gut microbiota in response to pathogens.

  • Circadian rhythms influence metabolism, immune responses, and microbial exposure in organisms.
  • There is a bidirectional interaction between host circadian clocks and gut microbiota.
  • Host circadian clocks may enhance the immune system's ability to combat pathogen infections.
  • Circadian clocks have direct effects on viral activity, including the entry and replication of SARS-CoV-2.
  • Strategies to realign circadian rhythms, such as chronotherapy and dietary changes, could support host health.

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