Progress in brain research

Daily timing signals from the brain's internal clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The suprachiasmatic nuclei (SCN) generate an endogenous ∼24-h circadian rhythm that influences various daily body functions.

  • Vasopressin may play a role in regulating circadian hormone rhythms.
  • SCN-derived prokineticin 2 (PK2) could be involved in controlling other circadian rhythms, such as locomotor activity, body temperature, and energy metabolism.
  • Transforming growth factor-alpha (TGF-α) and cardiotrophin-like cytokine (CLC) may also serve as output factors in circadian rhythm regulation.
  • The firing activity of SCN neurons is likely a critical mechanism for output signaling related to circadian rhythms.

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