Circadian phase typing in idiopathic generalized epilepsy: Dim light melatonin onset and patterns of melatonin secretion—Semicurve findings in adult patients

The mean dim light melatonin onset (DLMO) time in patients with idiopathic generalized epilepsy (IGE) was 49 minutes later than that in healthy controls.

• Patients with IGE had a mean Morningness-Eveningness Questionnaire (MEQ) score of 49.1, which was significantly lower than that of patients with cryptogenic focal epilepsy (56.1).
• No significant differences were found in midsleep times between patients with IGE, patients with focal epilepsy, and healthy controls.
• The melatonin surge within 30 minutes after DLMO was significantly lower in patients with IGE (1.51 pg/mL) compared to healthy controls (3.8 pg/mL).
• Subjective measures do not indicate a clear evening-oriented chronotype in patients with IGE.
• The findings suggest that patients with IGE may have a delayed circadian phase related to melatonin secretion.

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