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Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis
Daily biological rhythms and their links to cancer stem cells and tumor surroundings during cancer spread
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Abstract
Circadian disruption is associated with enhanced tumor formation and metastasis.
- The circadian clock regulates daily rhythms of physiological activities by modulating gene expression and biochemical functions.
- Disruption of circadian rhythms may lead to dysregulation of biological processes related to cancer progression.
- Cancer stem cells (CSCs) and their local tumor environments are influenced by circadian rhythms.
- Targeting circadian mechanisms could offer new strategies to eliminate tumor-resident CSCs and inhibit metastasis.
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