Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions

Circadian rhythm disruption (CRD) is increasingly recognized as a central driver of Alzheimer's disease pathology.

• CRD may exacerbate oxidative stress, inflammation, and gut microbiome imbalances, which can impair sleep and metabolic health.
• Oxidative stress, linked to neuronal damage, is both a cause and a consequence of circadian misalignment.
• Mitochondrial dysfunction may further amplify oxidative damage, negatively affecting synaptic function and cognitive stability.
• Gut microbiome dysbiosis is associated with increased neuroinflammation, which could worsen neurodegeneration.
• Time-restricted feeding (TRF) could help restore circadian function and improve aspects of health impacted by CRD, such as oxidative stress and gut microbiome diversity.

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