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Abstract
Circadian rhythms may influence the effectiveness of immunotherapy in cancer treatment.
- Immunotherapy, including cellular therapy, is becoming an important part of cancer care alongside surgery, chemotherapy, and radiotherapy.
- Only a limited number of patients respond well to immunotherapy, prompting studies on the tumor microenvironment (TME).
- Circadian regulation could affect immune cell behavior and cytokine production within the TME.
- Timing of treatments like adoptive cellular therapy and immune checkpoint blockade therapy may improve their effectiveness.
- Understanding how circadian rhythms interact with immunotherapy is crucial for enhancing cellular functions in the TME.
- Future clinical approaches may incorporate circadian rhythms to boost responses to immunotherapy.
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