New ways to activate the tumor environment and boost its response

The tumor microenvironment (TME) is crucial in cancer progression and treatment strategies.

• The TME is a complex ecosystem that influences both primary and metastatic tumors.
• Dynamic features of the TME are essential for understanding cancer evolution.
• Cancer progression is affected by various systemic factors, including metabolism and the gut microbiome.
• 'Cold' tumors may be less responsive to treatment compared to 'hot' tumors.
• Strategies to convert 'cold' tumors into 'hot' ones could enhance therapeutic efficacy.

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