How the Body’s Internal Clock Controls Tumor Cells and the Immune Environment

Circadian core genes are involved in regulating cell cycle checkpoints and metabolic homeostasis, influencing tumor progression.

• The circadian rhythm system coordinates essential physiological functions to maintain homeostasis.
• Dysfunction of circadian core genes may contribute to malignant tumor progression.
• Circadian rhythms influence immune cell development and function, potentially affecting tumor immunity.
• Chronotherapy, which aligns treatment with circadian rhythms, has shown advantages in clinical settings.
• Optimizing drug dosage and timing could enhance anti-tumor efficacy while minimizing side effects.
• Clinical trials are evaluating small molecule modulators and novel treatment regimens that target circadian rhythms in cancer therapy.

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