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Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response
Interactions between disrupted body clocks and tumor growth, metabolism, and immune response
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Abstract
Long-term disruptions in circadian rhythms may impact cellular health and are associated with various health problems, including cancer.
- Circadian rhythm is a 24-hour system that regulates sleep, metabolism, hormone function, and immune responses.
- Disruptions from factors like shift work and jet lag can lead to a loss of normal cell growth regulation at the genetic level.
- This loss of regulation is linked to tumorigenesis and affects the body's ability to manage cancer cell detection and elimination.
- Circadian rhythm influences cellular functions related to cancer progression and immune cell activity.
- Understanding the interaction between circadian disruption and cancer may optimize the timing of tumor therapies and improve treatment outcomes.
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