The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

Oct 10, 2023Aging and disease

How Body Clock Changes Relate to Brain Diseases

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Abstract

A bidirectional relationship between circadian rhythms and neurological diseases has been reported.

Circadian rhythms coordinate various physiological and pathophysiological processes in the body.
Neurological diseases may disrupt circadian homeostasis, potentially increasing disease severity.
Optimizing treatments with circadian-based approaches could lead to better clinical outcomes.
Interventions may include adjusted dosing, lifestyle changes, and targeted therapies.
Current clinical outcomes in neurological diseases are considered unsatisfactory.

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Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases.

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The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective

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