Circadian Rhythms in Acute Respiratory Distress Syndrome: Molecular Mechanisms and Therapeutic Implications

Circadian rhythm disruption is a key factor in the development of acute respiratory distress syndrome (ARDS).

• Core clock proteins are involved in regulating crucial processes like inflammation and tissue repair.
• The ICU environment and underlying health conditions can impair biological clocks, worsening inflammation and organ damage.
• Strong preclinical evidence supports the link between circadian rhythms and ARDS, but high-quality human studies are lacking.
• There is uncertainty regarding the optimal timing of interventions to stabilize biological rhythms.
• Integrating biological rhythm stabilization into ARDS management may enhance precision medicine approaches.

AI simplified